• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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    • 专利摘要:
    The invention relates to a method and a device for the continuous, non-invasive determination of blood pressure by means of a photoplethysmographic system (10) comprising at least one light source (11) and at least one light detector (11) with a holder (13) on a Body part are arranged, which includes an artery. According to the invention, a device (15) is provided with which the contact pressure of the holder (13) on the body part (20) can be set or changed as a function of the mean blood pressure.
    公开号:AT512304A4
    申请号:T50211/2012
    申请日:2012-05-31
    公开日:2013-07-15
    发明作者:Juergen Dipl Ing Dr Fortin
    申请人:Cnsystems Medizintechnik Ag；
    IPC主号:
    专利说明:

    1 16008
    The invention relates to a method and a device for the continuous, non-invasive determination of the blood pressure with the aid of a photoplethysmographic system comprising at least one light source and at least one light detector, which are arranged on a body part which includes an artery
    The continuous non-invasive measurement of blood pressure continues to be a major challenge for metrology to date. The so-called "Vascular Unloading Technique" begins in the marketplace. This is due to a publication by Penäz (Digest of the IO01 International Conference on Medical and Biological Engineering 1973 Dresden), in which a finger is illuminated and a servo control keeps the registered flux constant.
    According to Penäz or "Vascular Unloading Technique" photoplethysmographic method. or in some publications also " Volume Clamp Method " called, was further improved. For example, EP 0 537 383 A1 (TNO) shows an inflatable finger cuff for non-invasive continuous blood pressure monitoring. The inflatable cylindrical space is pneumatically connected to a fluid source. An infrared light source and a detector are positioned on either side of the finger within the fixed cylinder. There is provided a valve for filling the cylinder with gas. Furthermore, electrical cables for the infrared light source and the detector are passed. US 4,510,940 A (Wesseling) and US 4,539,997 A (Wesseling) show devices for continuous non-invasive measurement of blood pressure. A fluid filled sleeve, a light source, a light detector, and a differential pressure amplifier are provided. Furthermore, the publication US 4,597,393 (Yamakoshi) shows a variant of the Pefiäz principle.
    In WO 00/59369 A2, improvements of the valve control and of the pressure generating system as well as different versions of the pressure cuffs (for example double cuff) at different extremities are shown. In WO 04/086963 A2 it is explained how one can use the double cuff in such a way that the blood pressure in a cuff is measured according to the Penäz principle, wherein in the other cuff an optimized control of the working point (setpoint SP) is made. WO 05/037097 A1 describes an improved second
    Control system for the Vascular Unloading Technique, where internal control loops represent quasi optimized conditions for the next external control loops.
    WO 2011/051822 Al describes how one can improve the signal quality of the Vascular Unloading Technique in order to then apply a method of pulse contour analysis for obtaining further parameters in the further sequence. WO 2011/051819 A1 describes an improved, exclusively digital method and device for the Vascular Unloading Technique.
    The procedure according to Penäz has been further developed in numerous patents and publications, but a fundamental disadvantage of the method could not be remedied: To obtain the blood pressure signal, a sensor preferably has to be attached to the finger, the contact pressure of which must be tracked in real time to the arterial blood pressure in the finger , This rapid pressure tracking can only be realized with corresponding expenditure. In all previous publications to a cuff is used, which is connected to a pump and a complex valve or valve system. The internal pressure of the cuff, which rests on the finger, is now regulated so that it corresponds to the arterial blood pressure. This is the case when the simultaneously measured photopiethysmographic signal is constant.
    The cuff pressure must ideally allow for rapid changes as they may occur in true arterial blood pressure, i. he has to deal with change frequencies up to about 20Hz. This represents a great effort for valve or valve system, pump and cuff, which one would like to spare. The present invention is intended to reduce this effort considerably.
    The object of the invention is to propose a method and a device for the continuous, non-invasive determination of the blood pressure or the blood pressure signal Pep (t) [mmHg] that is easy to implement and can be used without problems. It would be desirable if one needed only a photoplethysmographic system without a complex printing system. A photoplethysmographic system essentially consists of a light source (preferably LED) and a light detector (e.g., photodiode) and is well known in pulse oximetry. The resulting signal v (t) [dimensionless, unless it is limited to e.g. Liter is calibrated] is a measure of the volume in the finger 3 (plethysmography) - its pulsations correspond to the arterial blood volume. The DC component of the signal is determined by the thickness of the finger and its tissue portions, by the laminar-flowing venous blood and other factors such as ambient light. In addition, the photoplethysmographic signal v (t) but also contains variable proportions, which are mostly determined by the vessel wall of the finger artery. Finger arteries are among the blood vessels that can be narrowed by vasoconstriction (vasoconstriction) and dilated (vasodilation). These vasomotor changes alter the photoplethysmographic signal to such an extent that it can not be used directly for blood pressure measurement.
    According to the invention, this object is achieved in that the contact pressure p (t) of the photoplethysmographic system changes depending on the mean blood pressure, or is adapted to the mean blood pressure.
    A device according to the invention - based on a photoplethysmographic system with at least one light source and at least one light detector, which are fastened by a holder to a body part containing an artery - is characterized by a device with which the contact pressure p (t) of the holder to the Body part is variable depending on the mean blood pressure.
    The special feature is that the contact pressure p (t) [mmHg] or the contact pressure of the holder and thus the plethysmographic system is changed so that this or this on the mean blood pressure (Mean Arterial Blood Pressure MABP) is turned off. This mean blood pressure MABP changes relatively slowly in relation to the true pulsatile intra-arterial blood pressure pBp (t) - while for tracing the arterial blood pressure pBp (t) a pressure or cuff system is required, which has to process pressure signals up to 20Hz for the tracking of the mean blood pressure MABP pressure changes well below the frequencies of the pulsations sufficient. This may preferably be done with simple mechanical systems such as e.g. Stepper motors, linear actuators, etc. can be achieved, but also with simple pneumatic systems (finger cuffs) without complex valve systems. For a preferably adaptive control, it is first necessary to find the appropriate starting point. The fact is exploited that the 4
    Pulsations of the plethysmographic signal v (t) are greatest when the contact pressure p (t) corresponds to the mean blood pressure MABP. It is therefore initially adjusted the contact pressure p (t) until the pulsations are greatest (search phase). Then the adaptive tracking of the contact pressure p (t) is activated (measuring phase). The initial plethysmographic signal V0 occurring at this point is stored for the subsequent control,
    The regulation for the pressure correction is based on the fact that first the plethysmographic signal v (t) is filtered so strongly with a low-pass filter that it can be used for the readjustment of the contact pressure. This filtered " Low Frequency LF " Signal vu = (t) is compared with the initial plethysmographic signal V0 and the contact pressure p (t) is changed until the filtered signal vu = (t) again corresponds to the initial signal V0. For the compensation of the vasomotor changes the circumstance is used, that with the middle blood pressure the negative or systolic half wave of v (t) is the same size as the positive or diastolic half wave. If this is not the case, then as long as the operating point and thus the pressure adjusted until both half-waves are equal again.
    The plethysmographic signal v (t) obtained in this way does not yet correspond to the actual blood pressure signal pBP (t), since the absolute values of the blood pressure can not be determined in this way. Therefore, the blood pressure is measured by another standard intermittent method, e.g. Determined oscillometric method on the upper arm and calculated a transfer function for the photoplethysmographic signal v (t). After application of this transfer function to the plethysmographic signal v (t), the continuous noninvasive blood pressure signal peP (t) is present.
    The invention is explained in more detail below with reference to schematic representations and diagrams. Show it:
    1 shows the principle of photoplethysmography according to the prior art,
    Fig. 2 shows the principle of " Vascular Unloading Technique " according to the prior art, 5
    3 shows the measuring principle according to the invention,
    4 shows a diagram of the temporal change of the photoplethysmographic signal v (t) when the pressure changes p (t),
    5 shows a diagram of the S-shaped transfer function between the contact pressure p and the plethysmographic signal v (p),
    6 different plethysmographic signals v (t) at different contact pressures p on the basis of the S-shaped transfer function,
    7 shows changes in the S-shaped transfer function and plethysmographic signals in vasoconstriction,
    Fig. 8 is a tracking of the pressure on the S-shaped transfer function, as well
    Fig. 9 is a schematic representation of the device according to the invention, including control.
    Fig. 1 shows the principle of photoplethysmography. The schematically illustrated device essentially consists of a photoplethysmographic system 10 with at least one light source 11 (eg an LED) and at least one light detector 12 which generates a photoplethysmographic signal v (t). Light emitted by the body part, for example fingers 20, is the is primarily absorbed by arterial blood in the artery 21. The capillaries are indicated at 22, the finger veins at 23. Furthermore, the pulsatile pressure changes are indicated by bulges 24 of the artery 21. On the other side of the finger 20, the residual light is received by the light detector 12 and converted into an electrical signal v (t). The signal thus reflects the arterial blood volume curve or the diameter of the Flngeraterie inverted.
    Fig. 2 describes the principle of the " Vascular Unloading Technique ". To measure blood pressure non-invasively and continuously, the Vascular Unloading Technique was developed. The vascular wall of the finger artery is thereby kept relaxed by a pressure in an adjacent bracket or sleeve 13 is controlled so fast that this cuff pressure exactly the pressure in the
    Artery 21 in the finger 20 corresponds. This is the case when the resulting photoplethysmographic signal v (t) is kept constant. This principle requires a fast-reacting pressure and control system 14, which is preferably realized pneumatically with pump, fast valve or valve systems and the finger cuff 13.
    In Fig. 3, the measuring system according to the invention is shown. The fast-acting printing system of the Vascular Unloading Technique is very expensive and therefore expensive. The following considerations now show that it is not necessary to track the contact pressure p (t) so fast that the true pulsatile, arterial blood pressure pBp (t) is replicated. It is only important to adjust the contact pressure p (t) to the mean blood pressure MABP. This can be done with a pressure tracking method that is much slower or sluggish than the systems known from the Vascular Unloading Technique. Fig. 3 shows a holder 13 (e.g., finger clips) for the at least one light source 11 and the at least one light detector 12 for securing it to the body part or finger 20 having an artery 21. According to the invention, a device 15 is now provided with which the contact pressure of the holder 13 on the body part can be varied as a function of the mean blood pressure. The tracking can thus be with a simple stepper motor or actuator, but also with a slow valve or valve system or other suitable devices respectively.
    Before this tracking can begin, the initial contact pressure P0 of the new measuring device must be set to the mean blood pressure MABP. It has been found that the contact pressure of a photoplethysmographic system then corresponds to the mean blood pressure MABP when the signal amplitude of the photoplethysmographic signal v (t) is greatest. FIG. 4 shows how the photoplethysmographic signal v (t) changes with increasing pressure p (t). The black dot marks the pressure at which the amplitude of v (t) is greatest - it corresponds to the current mean blood pressure MABP. This operating point - initial contact pressure Po and initial plethysmographic signal Vo - is further stored by the system in a memory. Note the inverted behavior of the signal v (t), because during systole there is naturally more blood in the finger than in the diastole. A larger volume of blood increases the absorption of light and thus lowers the plethysmographic signal while at the diastole the plethysmographic signal decreases because of the lower
    7
    Absorption increases. Furthermore, the increasing pressure causes more and more blood to be expelled from the finger - which is why the plethysmographic signal v (t) increases with increasing pressure p (t).
    In Fig. 5 it is shown why the signal amplitude is greatest when the contact pressure corresponds exactly to the mean blood pressure MABP. Fig. 5 shows the S-shaped transfer function between pressing pressure p and the plethysmographic signal v (p). This S-curve arises - in the theoretical case - when initially no pulsations occur in the artery and the plethysmographic signal v (p) versus the contact pressure p is plotted. Due to the actual arterial pulsations, the plethysmographic signal v (t) begins to oscillate around the operating point, which is set by the contact pressure.
    The amplitude of the generated plethysmographic signal v (t) is determined by the slope of the S-curve. In Fig. 5, the operating point corresponds to the inflection point of the S-curve, at which the largest slope and thus the largest plethysmographic amplitude can be determined. This point corresponds to the mean blood pressure MABP.
    FIG. 6 shows how the plethysmographic signal changes when the contact pressure is less than or greater than the mean blood pressure. If the contact pressure is too low, the plethysmographic signal v <(t) is produced. In contrast to v0 (t), the plethysmographic signal at medium pressure, the amplitude is smaller, but also the signal shape is changed. The systole appears wider, you can see the waveform as &quot; bulbous &quot; describe. In contrast, if the pressure is too high, the plethysmographic signal is v> (t) "sharpener" as v0 (t) as well as v <(t). Again, the amplitude is smaller.
    After the search of the largest amplitude, which is found at the contact pressure p (t), which corresponds to the mean blood pressure MABP or the largest slope at the inflection point of the S-curve, the system stands at the initial measuring point. This operating point is now to be kept in a first consideration as follows: The initial plethysmographic signal V0 as well as the initial contact pressure P0 are stored by the system as the initial operating point Vq / P0. δ
    Subsequently, the plethysmographic signal is filtered so that the pulsatile pressure changes largely disappear (see filter TPu in Fig. 9) and a slowly varying signal vu (t) arises, which can be easily adjusted by the inventive device 15 for pressure change. As a rule, the cutoff frequency of this filter is far below the frequencies of pulsatile pressure changes. This filtered signa! Vi_F (t) is compared with the initial operating point V0 and in the event of a deviation, the contact pressure p (t) is readjusted until the signal Vo is reached again.
    Such a change in pressure corresponds in the diagram of the S-shaped transfer function to a simple shift of the S-curve to the left at higher pressure or to the right at lower pressure (not shown). Unfortunately, there may also be a simultaneous reduction of the S-curve, which corresponds to a constriction of the artery (so-called vasoconstriction according to arrow 25) (see Fig. 7). In an enlargement of the artery (so-called vasodilation), the S-curve becomes larger analogous to FIG. These changes of the S-shaped transfer function by vasomotor changes (vasoconstriction or vasodilation) can be considered as follows: First, one must keep in mind that these changes occur only very slowly and in the minute range. In this &quot; very low frequency VLF &quot; Range can not be distinguished between blood pressure change or Vasomotorik and therefore this frequency range is completely removed by low-pass filtering (see filter TPvlF in Fig. 9) by means of a signal WlfOO. In the present practice, this means that the comparison with the initial operating point Vo is not permissible, because this could have shifted upwards by vasoconstriction or by vasodilation.
    Physiologically, the following happens: vasoconstriction narrows the blood vessel and thus less blood in the artery. Thus, the absorption is lower and the plethysmographic signal becomes larger, which corresponds to shifting the working point upward (see Fig. 7). Conversely, the artery is dilated during vasodilation and more blood is in the artery. Consequently, the absorption increases, the plethysmographic signal decreases and the operating point migrates downwards. 9
    In Fig. 7 it can be seen that not only the operating point moves but also the signal form vi (t) is changed - it becomes &quot; bulbous &quot; and corresponds to the signal v <(t) when the contact pressure is too low. Furthermore, one recognizes that the negative half-wave (-) of vi (t) becomes larger than the positive (+). The operating point Vo is readjusted (Vaigo) until both half-waves are equal again and v2 (t) is formed (FIG. 8). The change of V0 by Vaigo is now the new working point for the filtered plethysmographic signal. The contact pressure p (t) is changed until V0 plus Vaig0 again equals the filtered plethysmographic signal VlfOO.
    According to FIG. 9, the regulation of the device according to the invention preferably has two controlled systems each beginning with the low-pass filters TPLf and TPvlf. The one changes the contact pressure p (t) until the filtered plethysmographic signal VLF (t) corresponds to a desired value. This setpoint comes from the second controlled system and consists of the initial operating point V0 plus an adaptive value Vaigo · Vaigo is increased if the negative half-wave of the unfiltered plethysmographic signal v (t) - WLF (t) is greater than the positive half-wave. If both shark waves are the same size, Vaig0 remains unchanged, if the positive half wave is larger then Vaigo sinks.
    To be able to calculate the continuous blood pressure signal from these signals, a calibration has to be carried out with a conventional sphygmomanometer which determines the systolic sBP and the diastolic dpP blood pressure. Typically, a conventional sphygmomanometer does not measure mean blood pressure, but it can be determined according to the known formula mBP = dBP + 0.33 * (sBP-dBP).
    Furthermore, it is advantageous if the device according to the invention also measures the true contact pressure p (t) by means of a pressure sensor which corresponds to the mean blood pressure. The blood pressure signal pBp (t) can then be determined as follows: Pβp (t) = mBP + p (t) -P0 + (sBP-dBP) / (Vosys-VOdia) * v (t) 10 where V0sys and V0dia correspond to the systolic and / or Vdia Diastolic plethysmographic signal that occurred during or immediately after upper arm measurement.
    According to one embodiment, a direct measurement of the contact pressure p (t) with a pressure sensor can be omitted since the contact pressure p (t) can also be determined from the position of the actuator (for example from the position of the stepping motor) from the initial search phase. At the transition from search phase to measurement phase, as is well known, the contact pressure p (t) is at the mean blood pressure MABP. If the upper arm blood pressure is then determined immediately, then the following applies: p (t) = MABP = mPB = P0. For the course of the measurement and for the course of the contact pressure p (t), the position of the stepping motor is - at least relatively - information.
    The advantages of the new measuring method and the new measuring device are summarized above all in that the contact pressure p (t) or the contact pressure of the photoplethysmographic system is regulated to the mean blood pressure MABP. This pressure varies relatively slowly relative to the true pulsatile blood pressure pep (t) and may preferably be achieved with simple mechanical systems such as e.g. Stepper motors, linear actuators but also simple finger cuffs, can be achieved without complex valve systems. The pressure tracking control is based on the fact that firstly the plethysmographic signal is filtered so much that it can be used for the readjustment of the contact pressure, i. slow enough for the sluggish mechanical contact pressure system. This filtered signal vLF (t) is compared with the initial plethysmographic signal V0 and the contact pressure p (t) changed until the filtered signal νυ (ί) again corresponds to the initial signal V0. Furthermore, compensation for vasomotor changes is possible. The resulting plethysmographic signal is calibrated using a known, intermittent standard method.
    权利要求:
    Claims (15)
    [1]
    11. A method for the continuous, non-invasive determination of the blood pressure with the aid of a photoplethysmographic system comprising at least one light source and at least one light detector, which are arranged on a body part containing an artery, characterized in that the Contact pressure of the photoplethysmographic system is changed depending on the mean blood pressure, or is adapted to the mean blood pressure.
    [2]
    2. The method according to claim 1, characterized in that the rate of change of the contact pressure of the photoplethysmographic system is smaller than that of the pulsatile changes in blood pressure in the artery.
    [3]
    3. The method according to claim 1 or 2, characterized in that in a search phase of the initial contact pressure (P0) of the photoplethysmographic system is determined, in which the initial photoplethysmographic signal (V0) is formed with the largest amplitude.
    [4]
    4. The method according to claim 3, characterized in that in a search phase of the initial contact pressure (Po) and the initial photoplethysmographic signal (V0) are determined with the largest amplitude and from an initial operating point (V0 / Pq) is determined and stored.
    [5]
    5. The method according to any one of claims 1 to 4, characterized in that the contact pressure p (t) of the photoplethysmographic system is controlled starting from the initial contact pressure by a control system.
    [6]
    6. The method according to claim 5, characterized in that the control system generates a filtered photoplethysmographic signal vLF (t), which is compared with the initial photoplethysmographic signal (V0). 12
    [7]
    7. The method according to claim 5 or 6, characterized in that the control system takes into account physiological changes in the arterial vessel wall, such as vasomotor changes, by a low-pass filtering of the photoplethysmographic signal.
    [8]
    8. The method according to claim 7, characterized in that the control system detects physiological changes in the arterial vessel wall by comparing the pulsatile photoplethysmographic signal components.
    [9]
    9. Method according to one of claims 1 to 8, characterized in that the blood pressure signal derived from the photoplethysmographic measurement is measured by means of an intermittent blood pressure measurement, e.g. a upper arm, is calibrated.
    [10]
    10. The method according to claim 9, characterized in that for the calibration of the blood pressure signal, the mean blood pressure of the intermittent upper arm, the contact pressure of the photoplethysmographic system and possibly the pulsatile photoplethysmographic signal components are used.
    [11]
    11. The method according to claims 1 to 11, characterized in that the contact pressure is determined from the manipulated variables necessary for the tracking.
    [12]
    12. An apparatus for the continuous, non-invasive determination of blood pressure with a photoplethysmographic system (10), comprising at least one light source (11), preferably an LED, at least one light detector (12), preferably photodiode, the or a photoplethysmographic signal and a mount (13) for attaching the at least one light source (11) and the at least one light detector (12) to a body part (20) containing an artery (21),

    characterized in that a device (15) is provided, with which the contact pressure of the holder (13) to the body part (20) in dependence on the mean blood pressure is variable.
    [13]
    13. The device according to claim 12, characterized in that the device (15) achieves a rate of change of the contact pressure of the photoplethysmographic system (10) which is smaller than that of the pulsatile changes in blood pressure in the artery (21) of the body part (20).
    [14]
    14. Apparatus according to claim 12 or 13, characterized in that the means (15) for changing the contact pressure comprise a mechanical, pneumatic, electromagnetic or electromotive interlocking mechanism, such as a control unit. a stepping motor, a linear actuator, etc.
    [15]
    15. Device according to one of claims 12 to 14, characterized in that the means (15) for the change of the contact pressure is associated with a control system which from the photoplethysmographic signal (v (t)) of the photoplethysmographic system (10) with a first Filter (TPlf) derived from Pulsatilen pressure changes signal (vu <t)) and with a second filter (TPvlf) derived from vasomotor changes purified signal (WlfOO). 2012 05 31 Lu
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    ATA50211/2012A|AT512304B1|2012-05-31|2012-05-31|Method and device for continuous, non-invasive determination of blood pressure|ATA50211/2012A| AT512304B1|2012-05-31|2012-05-31|Method and device for continuous, non-invasive determination of blood pressure|
    CN201380040546.3A| CN104822314B|2012-05-31|2013-05-16|The method and apparatus that blood pressure is determined for continuous, non-invasive|
    US14/404,095| US10098554B2|2012-05-31|2013-05-16|Method and device for continuous, non-invasive determination of blood pressure|
    JP2015514413A| JP6219378B2|2012-05-31|2013-05-16|Method and apparatus for continuous noninvasive measurement of blood pressure|
    EP13724786.2A| EP2854626B1|2012-05-31|2013-05-16|Method and device for continuous, non-invasive determination of blood pressure|
    PCT/EP2013/060113| WO2013178475A1|2012-05-31|2013-05-16|Method and device for continuous, non-invasive determination of blood pressure|
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